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Hematology & Oncology


The medical field of hematology is concerned with both benign and malignant forms of blood diseases while the field of oncology is concerned with cancer. AOP Orphan has taken a particular interest in myeloproliferative disorders. This group of disorders of the bone marrow is characterized by the autonomous proliferation of blood progenitor cells.

Essential thrombocythemia

Essential thrombocythemia is a disorder of the bone marrow characterized by a clear overproduction of platelets (thrombocytes). This overproduction of platelets can lead to an increased risk of blood clots (thrombus) and bleeding (hemorrhage).

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Polycythemia vera

Polycythemia vera (PV) is a Rare Disease of the blood-building cells in the bone marrow primarily resulting in a chronic increase of red blood cells (erythrocytes), thereby decreasing the flowability of blood.

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Primary myelofibrosis

Primary myelofibrosis is a disorder of the bone marrow and is currently classified as a myeloproliferative disease in which the proliferation of an abnormal type of bone marrow stem cell results in fibrosis or the replacement of the marrow with collagenous connective tissue.

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Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML) is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood.

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